Nicholas Khan

July 30, 2022 in SARMS

Cardarine (GW501516) is a research chemical, but in the fitness world it is much more recognized as an orally active supplement. It is a widely held belief amongst some sports enthusiasts that if you are not using this supplement to improve your fitness, you will likely fall behind your peers – whatever sporting activities you may be into and especially those that involve endurance. In this review, we will take a detailed look at Cardarine (GW501516) and attempt to separate fact from fiction.

In this post, we will review Cardarine (GW501516), a product which is gaining far more attention than most other SARMs, and also discuss its benefits and side effects.

What is Cardarine (GW501516)?

Cardarine, aka GW501516, refers to an active chemical that was originally developed for reducing the size of tumors found in the colon, breasts, or prostrate. It later became popular with serious athletes and, in general, and is now utilized in the domain of competitive sports. 

Cardarine (GW501516) is actually a PPAR, or peroxisome proliferator activated receptor. PPARs usually refer to drugs that can lower the blood sugar level found in the body. There happens to be some misunderstanding about the nature of this drug – whether it is a PPAR or SARM.

 Cardarine (GW501516) is not exactly a SARM, but very much a PPAR. However, the confusion mainly stems from the fact that this supplement has properties and characteristics identical or similar to those that can be classified as SARMs. Hence, this confusion is understandable.

What Are The Benefits Of Using Cardarine (GW501516)?

There are multiple benefits to be gained from using Cardarine (GW501516). It is not for nothing that this research chemical is considered one of the best performance enhancing and fat burning compounds that you might come across. Let’s take a look at some of these benefits:

  • The first thing that you can expect from using this supplement is better cardiovascular performance. Studies have shown that Cardarine significantly improved the running ability of mice when subjected to endurance tolerance tests. You are likely to experience a remarkable boost in your stamina and endurance levels from using this drug.
  • The next important thing to note about Cardarine is that it really fast tracks the fat burning process. So, aside from having improved stamina, you can also shed fat rapidly. 
  • Cardarine also positively impacts the heart and blood vessels. A study conducted on mice showed that even after administering a small dose of this chemical to them, the damage in their arterial tissues got reduced. However, this study was only done on mice – so it is not completely certain if similar benefits will accrue to humans. 
  • It needs mentioning also that Cardarine is equipped with the ability to improve muscle growth. It activates the PPAR-Delta – by which process not only does excess fat melt away, but the muscle fibers receive stimulation also.
  • The natural hormone system of the body is not suppressed from using this drug. In contrast to RAD-140 (Testolone), Carderine will not adversely impact your testosterone levels, which implies it does not need a PCT, or post-cycle therapy.
  • It improves blood flow to the heart, resulting in more blood flowing to the muscles and extremities. This action of the drug reduces the risk of cardiac arrests and other cardiac ailments.
  • Cardarine facilitates brain functions and markedly brings down the possibility of brain strokes. 
  • It helps to control the fat cells, as earlier mentioned, and may prove in future to be a wonder cure for obesity. 
  • It enhances the sense of health and well being in the user – leading to better performance in professional life. 

What Does The Research Say?

Let’s take a deeper, and more technical, look at how Cardarine (GW501516) works in the human body. This chemical was designed in modern scientific labs using the latest in technology, and explaining how it works requires some technical jargon.

 Our body has nuclear receptors, only a few molecules in size, and these are tasked with sensing not only steroid molecules but other compounds as well. Once a nuclear receptor comes in contact with certain compounds, it activates biological functions.

Within this family of nuclear receptors there is a class known as PPARs, or peroxisome proliferator-activated receptors. These are further divided into beta (β) and delta (δ) groups. Cardarine was the result of research efforts by two pharmaceutical companies, Ligand Pharmaceuticals and GlaxoSmithKline (GSK), to help combat diseases. It works by activating your body’s PPAR-δ receptors

PPAR-δ receptors present in our fat tissues and muscles have two different functions. In the fat, or adipose, tissues, PPAR-δ enhances oxidation, which also helps in burning fat. In muscles, PPAR-δ increases the muscle fiber and fat burning actions.

Is It Legal?

As with any other supplement, we can gain some insight into the legality of using Cardarine (GW501516) by examining the way in which it is being used. The World Anti-Doping Agency, in 2009, included this product in its list of banned chemicals on the ground that it poses an undeniable health risk. Any breach of this ruling would invite the maximum penalty sanctioned by the association.

It is also considered illegal to sell GW501516 as a dietary supplement. However, there is no restriction on selling it as a research chemical product – and such an activity is considered completely legal. It can also be sold as a formulation for treating obesity, cholesterol and other such maladies. However, for athletes, it is illegal to use it for enhancing performance. 

Are There Any Side Effects?

Unfortunately, there could be potential side effects involving Cardarine (GW501516) for some people. Let’s consider them briefly:

  • It can give rise to fibrosis in people affected with liver disease.
  • It can result in an increasing number of cellular deaths in liver cells.
  • Studies have shown that Cardarine could cause cancer in laboratory mice and rats. However, this has not been conclusively proven.
  • Extended exposure to this drug can result in complications related to placental and fetal development.

Are There Legal/Natural Alternatives?

While inquiring into banned substances that some folks use for fat burning or muscle building, it is not unusual to come across safe alternatives that work with equal efficacy. Considering the fat burning and muscle building properties of Cardarine, we found Cardalean, manufactured by, as a safe and legal option.

Cardalean makes use of 3 proven amino acids – all of which help increase vascular flow, develop muscle, and burn fat. It helps your body to pump more blood to the muscles when exercising. This also makes more oxygen available to your body during a workout – which helps in burning fat.

  • L-Arginine is the first of those amino acids. It helps your body to maintain the nitric acid balance and regulate fat burning.
  • The next one that Cardalean uses is L-Citrulline. This is used by many health enthusiasts for bodybuilding – and justifiably so. It helps to increase the energy level and minimize muscle fatigue during a workout while burning fat at the same time. 
  • Lastly, Cardalean has an amino acid called L-Carnitine. This actually helps to move the fat cells into the core cells of your body – where they can be burned. .
  • In addition, Cardalean also includes 3 plant-based ingredients that help with fat burning, improving athletic performance, and maintaining optimum hormone levels. 
  • On the top of its ingredient list is wild yam. Scientific studies have established that this helps promote DHEA, a hormone that naturally occurs in the kidneys and assists in multiple biological functions. Getting your DHEA act together from a plant-based source could reduce your risk of losing hormone balance.
  • The next ingredient from Cardalean is ginseng. This, however, is not your run-of-the-mill ginseng – but a special variety called asian red ginseng, or panax ginseng. This particular kind of ginseng is certified by health experts to help improve blood flow, reduce fatigue, and maintain optimum testosterone level.

Best Alternative To Cardarine (GW501516)

All the 6 key ingredients included in Cardalean are of natural origin. They all help you lose weight, burn fat, and keep your muscles lean and strong. 

The manufacturer Brutal Force offers its customers a 100 day money back guarantee. If you aren’t satisfied, you don’t need to pay. For $119.98, you get two months’ supply of Cardalean, plus a free third month also. Moreover, you can also access their free video that helps you with your bulking and cutting cycles. The company provides all these options – but you can get them only from their website. 

Get Cardalean: #1 Natural Alternative To Cardarine (GW501516)

  • Safer, legal alternative to Cardarine (GW501516)
  • Faster muscle recovery times
  • Natural ingredients

Cardarine (GW501516) vs Alternatives: Our Recommendation

After taking a detailed look at Cardarine (GW501516), we are unable to recommend it. And that’s not only because it is banned, but also because of the unacceptable risks associated with its use. Exposing yourself to the possibility of contracting cancer in multiple organs isn’t exactly a prudent way to lose weight. It is worth noting the fact that the companies responsible for developing the drug gave up on it long while back – and these companies have excellent global reputations.

However, we have no hesitation in readily recommending Cardalean, brought to you by Brutal Force. It is a legal, safe, and an effective natural alternative for muscle building and fat burning. 

Cardarine (GW501516) – Pros & Cons

  • Helps in the formation of muscle fiber.
  • Lowers the risk of arteriosclerosis.
  • Improves endurance and stamina.
  • Does not adversely impact hormonal processes.
  • Helps maintain enhanced energy levels.
  • Helps in extensive fat dissipation.
  • Potentially cancer causing.
  • Liver toxicity not ruled out.
  • May cause insomnia.
  • May impair fetal development.
  • Possibility of brain damage.

Cardalean – Pros & Cons

  • It improves blood flow to the muscles, which allows you to train longer and harder than before.
  • Cardalean functions as an extreme fat burner without any side effects.
  • It enhances your body’s metabolism to burn fat, help with recovery and minimize muscle fatigue.
  • A safer option than Cardarine.
  • It boosts your energy level.
  • Cardalean can be ordered worldwide without any delivery charge.
  • The manufacturer of Cardalean does not support its offline sale – you can only order it from their website.


Is It Legal To Use Cardaine?

Not really. The USDA has made it illegal to use it for most purposes – except as a research chemical product and for certain illnesses.

Are There Any Side Effects From Using Cardarine?

In laboratory animals, Cardarine was observed to cause rapid cancer across multiple organs. This was considered dangerous enough to not test the drug on human subjects.

Can I Buy Cardarine Online?

If you are going to purchase something like Cardarine, you need to know the source. We have only found one reliable online retailer, SwissChems.

Is There A Good Alternative For Cardarine?

Yes. You can try out Cardalean for your fat burning and workout goals.

Is It Legal To Use Cardalean?

Yes. We recommend this product because Cardalean is legal and safe to use, and it works effectively as a muscle building supplement.

About the author 

Nicholas Khan

I am a certified fitness instructor and I write about supplements and testosterone products. I have been in the industry for over 10 years, and during that time, I have gained a lot of experience with different types of supplements. In my blog, I will discuss which ones work best for boosting testosterone levels and improving overall health.

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